In one model used in the study, DIPG is always fatal. When the two experimental compounds were given, however, 60% of the mice were still alive, when the experiments were ended.
“Treatments for DIPG are desperately needed. So, while these are still early stage, pre-clinical results, we are excited about continuing to develop this new strategy toward human clinical trials,” Venneti says.
DIPG is usually diagnosed in children between the ages of 5 and 10, though it can develop at any age, including rare cases in adults. These tumors start in the brainstem, which makes them nearly impossible to remove surgically. In 2015, Chad Carr, the grandson of former U-M football coach Lloyd Carr, died at age 5 after being diagnosed with the disease 14 months earlier.
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“The Chad Carr Pediatric Brain Tumor Center was started in 2018 and has placed the University of Michigan as one of the leading centers for DIPG research and patient care. We could not have performed this research without their strong support and critical funding from the Chad Tough Foundation,” Venneti says.
Both of the compounds used in the study — one of which was developed by the pharmaceutical company AbbVie and the other by Johns Hopkins University — are able to penetrate the blood-brain barrier, which is critical for treating brain tumors, Venneti adds.
“The barrier is there for a reason,” he says. “You don’t want toxins to be able to reach your brain. The challenge in developing drugs against brain cancer is that you need the drugs to be able to cross through this barrier and attack the tumor cells. We were fortunate that both of the study compounds can do so.”
The study also uncovered new information about the biology of DIPGs and related tumors through the analysis of cancer cells and imaging scans from DIPG patients. Along with shedding new light on the energy cycles of the cancer cells, researchers discovered why two different types of mutations — one seen in children with DIPG and the other observed in adult brain tumors — are mutually exclusive.
“We found that these two mutations use the same pathways, but in opposite ways, which explains why they can’t occur at the same time,” Venneti says.
Continuing to develop a better understanding of the underlying tumor biology will help researchers to develop and refine new treatment strategies, he notes.
The research was supported by the Chad Tough Foundation, National Institute of Neurological Disorders and Stroke (R01NS110572, K08-NS099427-01), Mathew Larson Foundation, St Baldrick’s Foundation, Claire McKenna Foundation, Alex Lemonade Stand Foundation, Storm The Heavens Foundation, a joint Chad Tough Foundation and Michael Mosier Defeat DIPG Foundation fellowship award, Sidney Kimmel Foundation, Doris Duke Foundation and Sontag Foundation, Taubman Research Institute, Rudi Schulte Research Institute, and the Ian’s Friends Foundation.
Additional authors include Chan Chung, Stefan R. Sweha, Drew Pratt, Pooja Panwalkar, Adam Banda, Jill Bayliss, Ho-Joon Lee, Mengrou Shan, Marcin Cieslik, Tingting Qin, Christian K. Werner, Daniel R. Wahl, Costas A. Lyssiotis, Vivekanand Yadav, Carl J. Koschmann and Arul M. Chinnaiyan, of U-M; Benita Tamrazi, Debra Hawes, Fusheng Yang , Stefan Blüml and Alexander R. Judkins, of the University of South California, Los Angeles; and Zhiguo Bian and J. Brad Shotwell of AbbVie.
Disclosure: Two of the co-authors are employees of AbbVie. One of the small molecule inhibitors used in the study was provided by the company. The company also participated in the interpretation of inhibitor data, review, and approval of the publication.
Paper Cited: “Integrated metabolic and epigenomic reprograming by H3K27M mutations in diffuse intrinsic pontine gliomas,” Cancer Cell. DOI: 10.1016/j.ccell.2020.07.008